The momentum of industrial operation is stable and improving
In 2023, the number of enterprises (including manufacturing, wholesale and retail) in the city's biomedical and health industry has reached 598 (474 pharmaceutical circulation enterprises, 79 pharmaceutical manufacturing enterprises, and 45 medical device manufacturing enterprises), achieving business income of 222.96 billion yuan, and achieving continuous improvement in industrial development and rising quantity and quality. The pharmaceutical manufacturing industry (including medical devices) achieved operating income of 42.44 billion yuan. Leading backbone enterprises are running steadily, Qilu Pharmaceutical, Freida Group and other 10 manufacturing enterprises with more than 1 billion yuan, 4 of which have a growth rate of more than 10%.
The policy service system has been gradually improved
Give full play to the role of the special class on the development of Jinan biomedicine and large health industry, establish a regular research and supervision mechanism, and carry out field visits to key enterprises and key projects in various districts and counties every quarter. Two policies and measures, including the Special Plan for the Development of Jinan Biomedicine and Large Health Industry (2023-2025), were issued and implemented. The policy of high-quality development awards and subsidies for the biomedical and health industries has been fully implemented, and 143 industrial projects have passed expert review, with a total of 180 million yuan of awards and subsidies for enterprises. Integrate the existing industrial funds, start the establishment of the municipal biomedical and large health industry mother fund, and plan to set up five sub-funds to further activate the financial "living water".
Remarkable progress has been made in the construction of key projects
In 2023, the special class for the development of Jinan biomedicine and health industry will adhere to the principle of "project is king", establish and improve the working mechanism for monthly scheduling and reporting of major projects, study and formulate project classification list, problem list and construction progress ledger, visit and study the key projects of biomedicine in the city one by one, and implement the full-cycle tracking service system of projects. We will accelerate project construction. By the end of 2023, there are 120 key projects in the city's biomedical industry, with a total investment of 81.249 billion yuan, and 18.875 billion yuan has been invested; There are 25 projects worth more than 1 billion yuan, with a total investment of 57.517 billion yuan, of which 12.221 billion yuan has been invested. Shandonghongri Kangren Tang Traditional Chinese Medicine Formula Granule project and ShandongSibert Biological Phase II Project have been mass produced, and projects such as Feilong Modern Pharmaceutical Industrial Park and Qilu Pharmaceutical biological drug super-large-scale preparation technology industrialization have been advanced in an orderly manner.
The level of industrial innovation has been accelerated
In order to continuously build and strengthen the industrial promotion system, Jinan City, in accordance with the overall idea of "focusing on the frontier, leading traction, innovation cultivation, creating ecology, planning along the chain, and cluster development", focuses on the "4+10+17" industrial system, and successively introduces 10 landmark industrial chain group implementation plans to further improve the chain group cultivation system and enhance the development level of industrial chain clusters. Two to three industrial clusters above the provincial level were added. Actively strive to be included in the overall layout of the provincial new industrialization demonstration zone to create a national new industrialization demonstration zone. Optimize the ecology of the park, promote the implementation of the innovative industrial land (M 9) policy, increase the planning of professional parks, and promote the accelerated landing of manufacturing projects. We will deepen the reform of the evaluation of "yield efficiency per mu", dynamically optimize the evaluation index system and evaluation methods, and implement differentiated allocation of resource elements.
In 2023, the city's biomedical enterprises invested more than 6 billion yuan in research and development, and key enterprises such as Qilu Pharmaceutical and Hongjitang accounted for more than 10% of the R&D investment. 65 new drug registration approvals were obtained in the city, accounting for 32.5% of the province; 195 new approval documents for 2-3 types of medical devices were obtained, accounting for 30% of the province; Fifty-eight varieties passed the generic drug consistency evaluation, accounting for 31% of the province; All ranked first in the province. 45 varieties were selected into the national drug centralized procurement list. Qilu Pharmaceutical Class 1 innovative drug Iruak tablet (Qixinke) was approved for market.
Solid chain and strong group achieved practical results
The role of the chain is obvious to all. In order to better strengthen the chain and extend the chain, Jinan City systematically sorted out the industrial chain atlas of the five subdivisions of biomedicine, traditional Chinese medicine, medical devices, medical beauty anti-aging, and special medical food, and developed three lists of chain master enterprises, attracting enterprises, and landing carriers. Give full play to the leading role of "chain master" enterprises such as Qilu Pharmaceutical and Huaxi Biological, and carry out accurate recruitment of four enterprises such as Sichuan Huili and Shanghai Lechun around the key links of the industrial chain.
Jinan continues to promote chain integration and chain strengthening activities, and in 2023, it will hold 2 special training sessions for the biomedical iconic industrial chain group, more than 10 large-scale exhibition activities such as the first China (Jinan) hyaluronic acid Industry Conference, more than 10 municipal biomedical docking activities, and reach more than 100 important cooperation intentions. Jinan biomedicine Industrial cluster was successfully approved as provincial advanced manufacturing cluster; Jinan medical beauty anti-aging industrial cluster, Jinan medical equipment cluster was selected as the province's "Top ten" industry "geese array" cluster; Jinan pharmaceutical manufacturing industry, Jinan High-tech Zone daily chemical product manufacturing (cosmetics) selected the Ministry of Industry and Information Technology consumer goods industry "three products" strategic demonstration city list.
An internationally competitive biomedical industry cluster will be built by 2024
The reporter learned from the special class on the development of Jinan biomedicine and large health industry that in 2024, Jinan will thoroughly implement the spirit of the industrial concept of "high point positioning, advance planning, fast work, innovative development", take project construction as the general starting point, take high-end and cluster as the development direction, and implement the landmark biomedical industry chain jump project. Actively build a better industrial ecology, and build a bio-pharmaceutical industry cluster with international competitiveness.
Strengthen operation monitoring and put quasi-industry "pulse"
In 2024, the Jinan Bureau of Industry and Information Technology and the special class for the development of biomedicine and large health industry will focus on strengthening the operation monitoring of the biomedicine industry, strengthening the analysis of monthly and quarterly reports, closely monitoring the production and operation of "chain master" enterprises, innovative enterprises, and key link enterprises in the chain, timely discovering trend problems, and making pre-research and pre-judgment and policy reserves. Focus on biomedical, traditional Chinese medicine, medical devices, medical anti-aging, special medical food and other subdivisions, in-depth investigation and research, open analysis one by one, highlight the problem "one net", "one industry and one policy" research detailed growth measures.
Keep an eye on project construction and seize the "power" of development
Projects are the cornerstone of development. In 2024, the relevant departments of Jinan City will focus on biomedical manufacturing projects, take into account project cultivation and industrial attraction, and "a bowl of water is flat". Adhere to the working mechanism of monthly scheduling and monthly reporting of major projects, on the basis of mapping and scheduling 120 key projects in the early stage, implement the quarterly steady growth plan, roll forward 5 key projects every quarter, and strive to form 1 billion yuan of incremental support. Sort out and refine the list of projects under construction, completion, planning and reserve, and rely on the forward tracking service to effectively alleviate the difficulties of enterprises. Focus on promoting Huatao Chinese medicine formula granules, Yingsheng precision medicine research and development and transformation production base and other projects to achieve results; Promote Buchang Pharmaceutical multidimensional pharmaceutical API production, Bainuo Pharmaceutical API industrial park and other projects to start.
Break through the subdivision field, polish Jinan "business card"
In the field of cosmetics, Jinan City has formed a certain scale and advantages. This year, the relevant departments will focus on the two segments of medical beauty anti-aging (cosmetics) and medical devices, establish an expert database of industrial talents, give full play to the role of "think tank" and "decision library", strengthen analysis and judgment, further clarify the "four beams and eight pillars" of the subdivision of the industrial chain, and optimize and improve the "industrial development map". Keep a close eye on the target to attract the latest trends of enterprises, timely communication and follow-up, field visits and investigations, and actively strive for cooperation intentions. The anti-aging industry chain focuses on the introduction of packaging materials supporting enterprises, and the medical device industry chain increases the attraction of platform-type enterprises. High-quality cosmetics industry conference, hyaluronic acid industry conference and other production and marketing docking, production and research cooperation activities, to build a multi-link direct docking channels, boost the "beauty makeup Jinan" brand construction.
Strengthen industrial clusters, create characteristic "model"
In order to strengthen the industrial cluster and create a characteristic "model", Jinan City will keep up with the new situation and new changes in industrial development this year, regularly comb and update the industrial chain map and N lists, plan key projects and attract enterprises along the chain, clarify the main direction and core tasks of the work, and formulate a good annual "battle map". Focus on promoting a number of strong chain supplement projects such as Changling High-tech Industrial Park, Buchang Pharmaceutical multidimensional medicine traditional Chinese medicine raw material production line, Zhongshan Aodatro bioenzyme synthesis and industrialization. Optimize and improve the spatial layout cluster ecology of "double core, double valley and multiple parks", give full play to the leading role of "chain master" enterprises, work hard and achieve results in promoting industrial collaboration and supporting, organizing major industry activities, and supporting the construction of service institutions, so as to promote Jinan biomedical advanced manufacturing cluster to the national level.
Optimize the development ecology, be a good enterprise "waiter"
A good business environment is the basis for attracting enterprises to invest and settle in, and it is also an indispensable important help for subsequent development. Jinan City will give full play to the role of the special class for the development of biomedicine and large health industry, regularly carry out field research, and smooth the "through train" demands of enterprises. Establish industry-university-research collaboration mechanisms in different fields and industries, and promote the establishment of gene and cell therapy, traditional Chinese medicine and other industrial associations (alliances). Support Qilu Pharmaceutical and other leading backbone enterprises to expand international industrial cooperation. Encourage medical institutions to give priority to the use of innovative products, and give a certain percentage of rewards according to the value of use. We strongly support Qilu Pharmaceutical, Keyuan Pharmaceutical, Mingren Freda and other enterprises to carry out CMO foundry business.
Actively strive for relevant supporting platforms to help high-quality development
At present, the city has 12 state-level innovation platforms. Among them, 2 national R&D platforms (National Comprehensive New drug R&D technology platform, National innovative drug incubation base), 4 national enterprise technology centers (Qilu Pharmaceutical, Freida, Huaxi Biological, Hongjitang Pharmaceutical), 2 National Engineering Technology Research Centers [National Research Center for Sugar Engineering Technology, Shandong University, Engineering Research Center for Pesticide Pharmaceutical Intermediates (Fine Chemicals), Shandong Normal University, Ministry of Education for Cleaner Production], 4 national key laboratories (State Key Laboratory of Microbial Technology, Shandong University, National Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, National Key Laboratory of Network Disease Theory Innovation and Transformation, Shandong First Medical University, National Key Laboratory of Advanced Drug Delivery System). It is mainly distributed in Lixia District and Jinan High-tech Zone, with universities, research institutes and leading enterprises as the main construction subjects. It has 219 provincial-level innovation platforms (100 science and technology innovation platforms, 101 engineering technology research centers, 2 manufacturing innovation centers, and 16 one-enterprise technology research and development centers).
In the next step, we will give full play to the leading role of the special class for the development of the biomedical industry, carefully sort out the construction of the supporting platform for the industry, decompose it to the responsible department, form a working ledger, regularly dispatch and summarize, report the progress to the municipal Party committee and city government in a timely manner, and effectively form a powerful driving force for the construction of a high-level platform to support the high-quality development of the biomedical industry.
To build a large platform for food, drug and medical devices, innovation and regulatory services
This year, Jinan City will continue to promote the National (Shandong) and Shandong Pilot Free Trade Zone (Jinan) food and drug medical device innovation and regulatory services platform project construction. The project was jointly built by the provincial Market Supervision Bureau, the provincial Drug Administration and the Jinan Municipal Government, and mainly built 15 centers and 52 laboratories for biological products and drug safety evaluation. Among them, the medical device innovation and regulatory service platform was completed and completed acceptance on October 29, 2023; Food and drug innovation and supervision service platform, part of the monomer main body has been capped, and the construction has entered the final stage.
To build a service platform for clinical transformation of advanced medical technology in Shandong Pilot Free Trade Zone. The Free Trade Zone, together with the Public Health Clinical Center of Shandong Province, creates a professional, standardized and open "one-stop" clinical transformation industry service platform, establishes clinical access and evaluation standards, provides safe, standardized and efficient clinical application services, and accelerates the research and development of advanced medical technology and the transformation of results of enterprises and scientific research institutions.
Construction of cell and gene therapy industry promotion platform in Shandong Free Trade Pilot Zone. The Free Trade Zone, together with Shandong University and Shandong University Qilu Hospital, relies on the policy advantages of the Free Trade zone to accelerate the construction of the province's first cell and gene therapy industry promotion platform in Lishan International Cell Industry Park, provides the whole industry chain public services such as cell extraction, preparation, storage, research and development, production and application, and accelerates the transformation and application of research results in the field of cell and gene.
We will strive for national policy support to improve the import facilitation of biomedical products
In order to improve the level of import facilitation of biomedical products, Jinan innovates the reform of customs clearance facilitation for biomedical products. The Jinan Area of the Free Trade Zone took the lead in the province in the import pilot of medicine and food homologous commodities, promoted the introduction of the "Pilot Plan for the reform of import Customs Clearance Facilitation of Medicine and food Homologous commodities", solved the trade control problems faced by food processing enterprises in the process of importing medicine and food homologous commodities, and allowed food processing enterprises to import medicine and food homologous commodities independently. To carry out the pilot of entry facilitation of special goods for biomedical research and development, and establish the "white list" system for the import of special goods for research and development by biomedical enterprises (R&D institutions), Jinan District is actively promoting enterprises to participate in the pilot work.
Innovative cell therapy regulatory system. The Jinan Area of the Free Trade Zone gives full play to the role of the cell and gene therapy industry promotion platform, and relies on the advantages of the expert team of Shandong University Qilu Hospital to explore the "risk classification and access classification" management of cell therapy. Cooperate with the provincial Free Trade Office and the Provincial Health and Health Commission, actively apply to the Ministry of Commerce and the National Health and Health Commission to carry out the pilot clinical transformation application of cell therapy in Jinan District, and further explore the compliance path for the clinical application of cell therapy.
We will formulate preferential tax measures for imported equipment for key research and development institutions. In order to reduce the research and development costs of enterprises and institutions, jointly with relevant departments to explore the formulation of relevant policies for the exemption of imported research and development equipment in the biomedical field of the free trade pilot zone, and designate research and development institutions and professional parks to carry out pilot projects to help scientific and technological innovation enterprises develop healthily and rapidly.
We will improve the public service system for biomedical innovation. Jinan District actively promotes the construction of public service platforms such as advanced medical technology clinical transformation industry service platform and cell and gene therapy industry promotion platform, and promotes the establishment of special construction funds for public service platforms.
Build a collaborative platform for production, learning, research and medicine
This year, Jinan will continue to promote the construction of existing national key laboratories, provincial key laboratories, technological innovation centers, innovation and entrepreneurship communities, new research and development institutions and other platform carriers, guide and support the construction of national key laboratories in universities, institutions and enterprises in Jinan, and cooperate with the provincial science and Technology Department to restructure the provincial key laboratories that have been built. The innovation platform that encourages enterprises to build focuses on the industry and the key common technologies of the industry, carries out basic research, applied basic research and modern engineering technology, and solves the problem of "stuck neck".
Guided by policies, we will strengthen the guarantee of factors and promote the transformation of innovative products of R&D enterprises in Jinan.
Encourage resident medical institutions or third-party clinical trial institutions to improve the basic conditions, establish a high-level clinical trial base, and ensure that the products of biomedical enterprises carry out clinical trials
Build an integrated pharmaceutical industrial park
In order to create a complete industrial chain and an integrated support service system, Jinan will speed up the construction of an integrated pharmaceutical industrial park that integrates park development, capital operation, achievement transformation, and enterprise service.
Accelerate the construction of Jinan High-Tech Zone Life Science City, Lishan International Biopharmaceutical production Base, Licheng Biomedical Port, Laiwu Luzhong International Biological Valley and other industrial parks, build around the industrial chain and build a complete industrial chain integrating research and development, raw material and preparation production, inspection and testing, results transformation, distribution, and enterprise services.
Focusing on the five industrial fields of biomedicine, traditional Chinese medicine, medical devices, medical beauty anti-aging, and special medical food, focusing on the weak links of the industrial chain and the key nodes of the strong chain and the extended chain of the supply chain, the orientation and target enterprises of the construction chain, strong chain, supplementary chain, and extended chain are planned along the chain. Focusing on the needs of existing enterprises, the precise implementation of supply and demand docking, and the construction of an integrated support service system of "government, industry, university, research and financing".
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